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Beate Schultheis Selected Research

Atu027

10/2020Safety, Efficacy and Pharcacokinetics of Targeted Therapy with The Liposomal RNA Interference Therapeutic Atu027 Combined with Gemcitabine in Patients with Pancreatic Adenocarcinoma. A Randomized Phase Ib/IIa Study.
12/2014First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors.
1/2012Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors.

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Beate Schultheis Research Topics

Disease

16Neoplasms (Cancer)
05/2018 - 04/2006
6BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
05/2007 - 03/2002
3Iron Deficiencies
01/2009 - 01/2007
3Blast Crisis (Blast Phase)
05/2007 - 09/2005
2Infections
08/2023 - 09/2012
2Pancreatic Neoplasms (Pancreatic Cancer)
10/2020 - 06/2012
2Myelodysplastic Syndromes (Myelodysplastic Syndrome)
04/2009 - 07/2007
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2009 - 01/2007
2Myeloproliferative Disorders (Myeloproliferative Disorder)
10/2006 - 09/2005
2Disease Progression
10/2005 - 09/2005
2Genetic Translocation (Chromosomal Translocation)
09/2005 - 08/2002
1Herpes Zoster
08/2023
1Hidradenitis Suppurativa
08/2023
1Chickenpox
08/2023
1Adenocarcinoma
10/2020
1Hemangiosarcoma (Angiosarcoma)
01/2018
1Breast Neoplasms (Breast Cancer)
01/2018
1Ovarian Neoplasms (Ovarian Cancer)
09/2017
1Fatigue
06/2017
1Nausea
06/2017
1Vomiting
06/2017
1Non-Hodgkin Lymphoma (Lymphosarcoma)
01/2016
1Sarcoma (Soft Tissue Sarcoma)
03/2015
1Lymphoma (Lymphomas)
03/2015
1Neoplasm Metastasis (Metastasis)
12/2014
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2013
1Aspergillosis
09/2012
1Pulmonary Aspergillosis
08/2012
1Hematologic Neoplasms (Hematological Malignancy)
08/2012
1Body Weight (Weight, Body)
03/2012
1Iron Overload
04/2009
1Exanthema (Rash)
04/2009
1B-Cell Lymphoma (Lymphoma, B Cell)
05/2007
1Hyperferritinemia
05/2007
1Hemochromatosis (Bronze Diabetes)
05/2007
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2006
1Pdgfra-Associated Chronic Eosinophilic Leukemia
10/2006
1Mastocytosis
04/2006
1Leukemia
02/2003
1Eosinophilia
08/2002

Drug/Important Bio-Agent (IBA)

6Imatinib Mesylate (Gleevec)FDA Link
03/2012 - 08/2002
3Atu027IBA
10/2020 - 01/2012
3IronIBA
04/2009 - 05/2007
3Transferrin Receptors (Transferrin Receptor)IBA
01/2009 - 01/2007
2Proteins (Proteins, Gene)FDA Link
12/2017 - 09/2005
2Antineoplastic Agents (Antineoplastics)IBA
11/2014 - 06/2012
2MicroRNAs (MicroRNA)IBA
11/2014 - 05/2007
2Messenger RNA (mRNA)IBA
10/2006 - 09/2005
2bcr-abl Fusion ProteinsIBA
04/2006 - 03/2002
2Tyrosine Kinase InhibitorsIBA
10/2005 - 08/2002
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2005 - 09/2005
1upadacitinibIBA
08/2023
1GemcitabineFDA Link
10/2020
1ChromograninsIBA
05/2018
1SynaptophysinIBA
05/2018
1Phosphopyruvate Hydratase (Enolase)IBA
05/2018
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2018
1Epirubicin (Ellence)FDA LinkGeneric
01/2018
1Aromatase InhibitorsIBA
01/2018
1Growth Factor ReceptorsIBA
12/2017
1Lenalidomide (CC 5013)FDA Link
09/2017
1Immunomodulating AgentsIBA
09/2017
1Thalidomide (Thalomid)FDA Link
09/2017
1Cyclin-Dependent Kinases (cdk Proteins)IBA
06/2017
1roniciclibIBA
06/2017
1Cyclin D1IBA
01/2016
1DesminIBA
03/2015
1Therapeutic UsesIBA
12/2014
1Cytostatic AgentsIBA
11/2014
1ParaffinIBA
11/2014
1Sunitinib (Sutent)FDA Link
01/2013
1galactomannanIBA
08/2012
1ErbB Receptors (EGF Receptor)IBA
06/2012
1nimotuzumabIBA
06/2012
1regorafenibIBA
06/2012
1Bevacizumab (Avastin)FDA Link
01/2012
1Small Interfering RNA (siRNA)IBA
01/2012
1Paclitaxel (Taxol)FDA LinkGeneric
01/2012
1Sorafenib (BAY 43-9006)FDA Link
01/2012
1CreatinineIBA
04/2009
1DeferasiroxFDA Link
04/2009
1C-Reactive ProteinIBA
01/2009
1Ferritins (Ferritin)IBA
01/2009
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
05/2007
1zinc protoporphyrinIBA
05/2007
1Heme (Haem)IBA
05/2007
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
10/2006
1Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA
08/2002

Therapy/Procedure

8Therapeutics
10/2020 - 04/2006
3Drug Therapy (Chemotherapy)
10/2016 - 09/2012
1Salpingo-oophorectomy
01/2018
1Segmental Mastectomy (Lumpectomy)
01/2018
1Adjuvant Chemotherapy
01/2018
1Cytoreduction Surgical Procedures
10/2016
1Premedication
12/2014
1Intravenous Infusions
12/2014
1Stem Cell Transplantation
09/2012
1Blood Transfusion (Blood Transfusions)
04/2009
1Chelation Therapy (Therapy, Chelation)
04/2009
1Haploidentical Transplantation
02/2003